Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2012 Jun;6(3):297-300.
doi: 10.2217/bmm.12.23.

HNF4α: a new biomarker in colon cancer?

Karthikeyani Chellappa, Graham R Robertson, Frances M Sladek
Editorial

HNF4α: a new biomarker in colon cancer?

Karthikeyani Chellappa et al. Biomark Med. 2012 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Financial & competing interests disclosure

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

References

    1. Lazarevich NL, Shavochkina DA, Fleishman DI, et al. Deregulation of hepatocyte nuclear factor 4 (HNF4) as a marker of epithelial tumors progression. Exp. Oncol. 2010;32(3):167–171. - PubMed
    1. Hatziapostolou M, Polytarchou C, Aggelidou E, et al. An HNF4alpha–miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell. 2011;147(6):1233–1247. - PMC - PubMed
    1. Chellappa K, Jankova L, Schnabl JM, et al. Src tyrosine kinase phosphorylation of nuclear receptor HNF4alpha correlates with isoform-specific loss of HNF4alpha in human colon cancer. Proc. Natl Acad. Sci. USA. 2012;109(7):2302–2307. - PMC - PubMed
    1. Schwartz B, Algamas-Dimantov A, Hertz R, et al. Inhibition of colorectal cancer by targeting hepatocyte nuclear factor-4alpha. Int. J. Cancer. 2009;124(5):1081–1089. - PubMed
    1. Oshima T, Kawasaki T, Ohashi R, et al. Downregulated P1 promoter-driven hepatocyte nuclear factor-4alpha expression in human colorectal carcinoma is a new prognostic factor against liver metastasis. Pathol. Int. 2007;57(2):82–90. - PubMed

Website

    1. Bolotin E, Schnabl J, Sladek F. HNF4A (homo sapiens). Transcription factor encyclopedia. www.cisreg.ca/cgi-bin/tfe/home.pl.

Publication types

MeSH terms

Substances