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Review
. 2012 Jul;40(3):159-64.
doi: 10.1097/JES.0b013e3182575599.

Exercise training-induced regulation of mitochondrial quality

Zhen Yan  1 , Vitor A Lira, Nicholas P Greene
Affiliations
Review

Exercise training-induced regulation of mitochondrial quality

Zhen Yan et al. Exerc Sport Sci Rev. 2012 Jul.

Abstract

Mitochondria are dynamic organelles in skeletal muscle critical in physical performance and disease. The mitochondrial life cycle spans biogenesis, maintenance, and clearance. Exercise training may promote each of these processes, conferring positive impacts on skeletal muscle contractile and metabolic functions. This review focuses on the regulation of these processes by endurance exercise and discusses potential benefits in health and disease.

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Conflict of interest statement

Conflict of Interest: The authors (Z.Y., V.A.L., N.P.G.) declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of exercise-induced mitochondrial maintenance. Exercise is proposed to promote biogenesis, fusion, fission, and mitophagy in an effort to both promote the formation of new mitochondria and the identification and removal of damaged and dysfunctional mitochondria to improve metabolic function.
See this image and copyright information in PMC

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