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Review
. 2012 Jun 26;125(25):3220-8.
doi: 10.1161/CIRCULATIONAHA.111.033878.

Genetics of peripheral artery disease

Nicholas J Leeper  1 , Iftikhar J Kullo, John P Cooke
Affiliations
Review

Genetics of peripheral artery disease

Nicholas J Leeper et al. Circulation. .
No abstract available

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Conflict of interest statement

Conflict of Interest Disclosures: None

Figures

Figure 1
Figure 1
The Genetics of PAD. Factors associated with risk of peripheral arterial disease include variation in the genetic code (e.g. single nucleotide polymorphisms or SNPs) and epigenetic DNA modifications (e.g. cytosine methylation). Post-transcriptional regulation by non-coding RNAs may also alter expression of gene products relevant to vascular homeostasis. Finally, recently appreciated mitochondrial DNA variation and complex gene-by-environment interactions may also be involved in PAD pathogenesis, as discussed in the text.
See this image and copyright information in PMC

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