Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct;369(1-2):27-33.
doi: 10.1007/s11010-012-1365-0. Epub 2012 Jun 24.

NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells

Zhujun Tan  1 , Maolan Li, Wenguang Wu, Lin Zhang, Qichen Ding, Xiangsong Wu, Jiasheng Mu, Yingbin Liu
Affiliations

NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells

Zhujun Tan et al. Mol Cell Biochem. 2012 Oct.

Erratum in

Abstract

Gallbladder cancer (GBC) is one of the most lethal neoplasm and is the fifth most common malignancy of gastrointestinal tract. The prognosis of gallbladder cancer is extremely terrible partially due to metastasis. Thus, understanding the molecular pathways controlling metastasis of this lethal disease may provide new targets for targeted therapeutic approach. In this study, we investigated the function of nemo-like kinase (NLK) in GBC growth and migration. Lentivirus-mediated siRNA was employed to alleviate the expression level of NLK in GBC cell lines (GBC-SD and SGC-996). Real-time PCR and western-blot analysis demonstrated that both mRNA and protein levels of NLK in GBC-SD and SGC-996 cells were decreased after infection with NLK-siRNA-expressing lentivirus (Lv-shNLK). The proliferation and in vitro tumorigenesis (colony formation) ability as well as migration of GBC-SD and SGC-996 cells with low NLK expression decreased significantly. Our results suggested that NLK is a key regulator involved in proliferation and migration of GBC, and it could be used as a potential therapeutic target for GBC.

PubMed Disclaimer

References

    1. Mech Dev. 2002 Nov;119(1):9-20 - PubMed
    1. J Biol Chem. 2006 Jul 28;281(30):20749-20760 - PubMed
    1. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):963-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7421-6 - PubMed
    1. Am J Surg. 2008 Aug;196(2):252-64 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources