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. 2012 Oct;26(10):1675-81.
doi: 10.1210/me.2012-1077. Epub 2012 Jun 25.

Research resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) consortium interconnectivity network: a pilot program to aggregate research resources generated by multiple research consortia

Neil J McKenna  1 , Christopher L Howard, Michael Aufiero, Jeremy Easton-Marks, David L Steffen, Lauren B Becnel, Mark A Magnuson, Richard A McIndoe, Jean-Philippe Cartailler
Affiliations

Research resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) consortium interconnectivity network: a pilot program to aggregate research resources generated by multiple research consortia

Neil J McKenna et al. Mol Endocrinol. 2012 Oct.

Abstract

The National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) supports multiple basic science consortia that generate high-content datasets, reagent resources, and methodologies, in the fields of kidney, urology, hematology, digestive, and endocrine diseases, as well as metabolic diseases such as diabetes and obesity. These currently include the Beta Cell Biology Consortium, the Nuclear Receptor Signaling Atlas, the Diabetic Complications Consortium, and the Mouse Metabolic Phenotyping Centers. Recognizing the synergy that would accrue from aggregating information generated and curated by these initiatives in a contiguous informatics network, we created the NIDDK Consortium Interconnectivity Network (dkCOIN; www.dkcoin.org). The goal of this pilot project, organized by the NIDDK, was to establish a single point of access to a toolkit of interconnected resources (datasets, reagents, and protocols) generated from individual consortia that could be readily accessed by biologists of diverse backgrounds and research interests. During the pilot phase of this activity dkCOIN collected nearly 2000 consortium-curated resources, including datasets (functional genomics) and reagents (mouse strains, antibodies, and adenoviral constructs) and built nearly 3000 resource-to-resource connections, thereby demonstrating the feasibility of further extending this database in the future. Thus, dkCOIN promises to be a useful informatics solution for rapidly identifying useful resources generated by participating research consortia.

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Figures

Fig. 1.
Fig. 1.
dkCOIN is a nexus for biologically related resources in NIDDK research consortium websites. Members of the Slc2 family of facilitated glucose transporters exemplify biological relationships between dkCOIN consortia. Icons identified in the resource key represent specific resources (datasets or reagents) generated and curated by individual dkCOIN participants and interconnected by dkCOIN. Gray ovals represent specific orthologs of Slc2 family gene orthologs.
See this image and copyright information in PMC

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