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. 2012 Jun 26:10:118.
doi: 10.1186/1477-7819-10-118.

Outcome analysis of breast cancer patients who declined evidence-based treatment

Kurian Joseph  1 , Sebastian Vrouwe, Anmmd Kamruzzaman, Ali Balbaid, David Fenton, Richard Berendt, Edward Yu, Patricia Tai
Affiliations

Outcome analysis of breast cancer patients who declined evidence-based treatment

Kurian Joseph et al. World J Surg Oncol. .

Abstract

Background: To analyze the characteristics and outcomes of women with breast cancer in the Northern Alberta Health Region (NAHR) who declined recommended primary standard treatments.

Methods: A chart review was performed of breast cancer patients who refused recommended treatments during the period 1980 to 2006. A matched pair analysis was performed to compare the survival data between those who refused or received standard treatments.

Results: A total of 185 (1.2%) patients refused standard treatment. Eighty-seven (47%) were below the age of 75 at diagnosis. The majority of those who refused standard treatments were married (50.6%), 50 years or older (60.9%), and from the urban area (65.5%). The 5-year overall survival rates were 43.2% (95% CI: 32.0 to 54.4%) for those who refused standard treatments and 81.9% (95% CI: 76.9 to 86.9%) for those who received them. The corresponding values for the disease-specific survival were 46.2% (95% CI: 34.9 to 57.6%) vs. 84.7% (95% CI: 80.0 to 89.4%).

Conclusions: Women who declined primary standard treatment had significantly worse survival than those who received standard treatments. There is no evidence to support using Complementary and Alternative Medicine (CAM) as primary cancer treatment.

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Figures

Figure 1
Figure 1
Survival of the breast cancer patients who received standard treatment compared to those who refused treatment in NAHR, 1980–2006. (a) All causes of deaths and (b) deaths due to breast cancer only.
Figure 2
Figure 2
Survival of the breast cancer patients who took CAM compared to those who did not take CAM in NAHR, 1980–2006; (a) all causes of deaths and (b) deaths due to breast cancer only.
See this image and copyright information in PMC

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