Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jul 20;14(14):3604-7.
doi: 10.1021/ol301331t. Epub 2012 Jun 26.

Total synthesis of (-)-FR901483

Ai-Jun Ma  1 , Yong-Qiang Tu, Jin-Bao Peng, Qing-Yun Dou, Si-Hua Hou, Fu-Min Zhang, Shao-Hua Wang
Affiliations

Total synthesis of (-)-FR901483

Ai-Jun Ma et al. Org Lett. .

Abstract

A total synthesis of the immunosuppressive alkaloid (-)-FR901483 (1) has been described. The intriguingly azatricyclic structure of 1 was constructed by the semipinacol-type rearrangement and intramolecular Schmidt reaction of an azido cyclohexanone derivative. This strategy provides a distinctive and competitive approach to the natural product 1.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources