Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized pilot RenPro Trial (Renal Protection Trial)
- PMID: 22735306
- DOI: 10.1161/CIRCULATIONAHA.112.096370
Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized pilot RenPro Trial (Renal Protection Trial)
Abstract
Background: Contrast medium-induced acute kidney injury is associated with substantial morbidity and mortality. The underlying mechanism has been attributed in part to ischemic kidney injury. The aim of this randomized, double-blind, sham-controlled trial was to assess the impact of remote ischemic preconditioning on contrast medium-induced acute kidney injury.
Methods and results: Patients with impaired renal function (serum creatinine >1.4 mg/dL or estimated glomerular filtration rate <60 mL · min(-1) · 1.73 m(-2)) undergoing elective coronary angiography were randomized in a 1:1 ratio to standard care with (n=50) or without ischemic preconditioning (n=50; intermittent arm ischemia through 4 cycles of 5-minute inflation and 5-minute deflation of a blood pressure cuff). Overall, both study groups were at high risk of developing contrast medium-induced acute kidney injury according to the Mehran risk score. The primary end point was the incidence of contrast medium-induced kidney injury, defined as an increase in serum creatinine ≥25% or ≥0.5 mg/dL above baseline at 48 hours after contrast medium exposure. Contrast medium-induced acute kidney injury occurred in 26 patients (26%), 20 (40%) in the control group and 6 (12%) in the remote ischemic preconditioning group (odds ratio, 0.21; 95% confidence interval, 0.07-0.57; P=0.002). No major adverse events were related to remote ischemic preconditioning.
Conclusions: Remote ischemic preconditioning before contrast medium use prevents contrast medium-induced acute kidney injury in high-risk patients. Our findings merit a larger trial to establish the effect of remote ischemic preconditioning on clinical outcomes.
Clinical trial registration: URL: http://www.germanctr.de. Unique identifier: U1111-1118-8098.
Comment in
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Limb ischemia protects against contrast-induced nephropathy.Circulation. 2012 Jul 24;126(4):384-7. doi: 10.1161/CIRCULATIONAHA.112.119701. Epub 2012 Jun 26. Circulation. 2012. PMID: 22735307 Free PMC article. No abstract available.
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Acute kidney injury: Ischaemic preconditioning for preventing contrast-induced AKI.Nat Rev Nephrol. 2012 Sep;8(9):492. doi: 10.1038/nrneph.2012.151. Epub 2012 Jul 17. Nat Rev Nephrol. 2012. PMID: 22801946 No abstract available.
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Letter by Mehta Oza and Raman regarding article, "Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized pilot RenPro Trial (Renal Protection Trial)".Circulation. 2013 Apr 2;127(13):e535. doi: 10.1161/CIRCULATIONAHA.112.141036. Circulation. 2013. PMID: 23547185 No abstract available.
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Response to letter regarding article, "Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized Pilot RenPro-Trial (Renal Protection Trial)".Circulation. 2013 Apr 2;127(13):e536. doi: 10.1161/circulationaha.112.147587. Circulation. 2013. PMID: 23662313 No abstract available.
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