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. 2012 May 1;1(3):380-382.
doi: 10.4161/onci.18801.

Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis

Sana Intidhar Labidi-Galy  1 , Isabelle Treilleux, Sophie Goddard-Leon, Jean-Damien Combes, Jean-Yves Blay, Isabelle Ray-Coquard, Christophe Caux, Nathalie Bendriss-Vermare
Affiliations

Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis

Sana Intidhar Labidi-Galy et al. Oncoimmunology. .

Abstract

Using two different and complementary approaches (flow cytometry and immunohistochemistry) on two independent cohorts of ovarian cancer patients, we found that accumulation of plasmacytoid dendritic cells (pDC) in tumors is associated with early relapse. This deleterious effect of tumor-associated pDC was evident when they are present in cancer epithelium but not in lymphoid aggregates.

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Figures

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Figure 1. The presence of plasmacytoid dendritic cells (pDC) in ovarian cancer (OC) epithelium is associated with early relapse. (A–C) IHC analysis on paraffin-embedded ovarian tumor sections was performed using anti-BDCA2 (brown). Representative pictures of BDCA2+ pDC infiltration of OC epithelium scored as 0 (A), + (B) and ++ (C) are shown. Original magnification: x40. (D) Progression-free survival (PFS) according to the presence (+/++) or absence (0) of BDCA2+ pDC in OC epithelium (n = 97 OC patients). (E) Overall survival (OS) according to presence (+/++) or absence (0) of BDCA2+ pDC in OC epithelium (n = 97 OC patients). PFS and OS were calculated using Kaplan–Meier method.
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