Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jun;27(4):275-9.
doi: 10.1177/1533317512449730.

Vascular risk factors and cardiovascular outcomes in the Alzheimer's disease neuroimaging initiative

Noam U Epstein  1 , Hui Xie, Sean D Ruland, Dilip K Pandey; Alzheimer’s Disease Neuroimaging Initiative
Affiliations

Vascular risk factors and cardiovascular outcomes in the Alzheimer's disease neuroimaging initiative

Noam U Epstein et al. Am J Alzheimers Dis Other Demen. 2012 Jun.

Abstract

Background: Vascular disease and medical factors are associated with cognitive decline and cardiovascular events. We examined the association between vascular risk factors and events in the Alzheimer's Disease Neuroimaging Initiative cohort.

Methods: The association between vascular risk factors and cardiovascular events in a cohort of 810 participants, including 400 with mild cognitive impairment, 184 with Alzheimer's, and 226 controls was investigated using a longitudinal hazard model.

Results: There were 31 events including 11 strokes, 7 myocardial infarctions, 5 revascularizations, and 8 deaths during an average follow-up of 31 months. Longitudinal cardiovascular event rates were low and similar between diagnostic groups.

Conclusions: All baseline vascular risk factors that were expected to be associated with longitudinal cardiovascular events were, or were trending toward, associating with cardiovascular events except atrial fibrillation, depression, and apolipoprotein E genotype. Despite differences in baseline vascular risk factors, longitudinal cardiovascular event rates were similar between diagnostic groups.

PubMed Disclaimer

Conflict of interest statement

The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr Ruland served as a speaker for Boehringer Ingelheim, consulted for Aztra Zeneca and both consulted and spoke for Otsuka.

References

    1. Williams J, Plassman B, Burke J, Holsinger T, Benjamin S. Preventing Alzheimer’s disease and cognitive decline. 2010. Report No.: 10-E005. - PMC - PubMed
    1. Wolf PA, D'Agostino RB, Belanger AJ, Kannel WB. Probability of stroke: a risk profile from the Framingham study. Stroke. 1991;22(3):312–318. - PubMed
    1. Kannel WB, Cupples LA, Ramaswami R, Stokes J, 3rd, Kreger BE, Higgins M. Regional obesity and risk of cardiovascular disease; the framingham study. J Clin Epidemiol. 1991;44(2):183–190. - PubMed
    1. Cholesterol Treatment Trialists' (CTT) Collaboration. Baigent C, Blackwell L, Emberson J, et al. . A meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010;376(9753):1670–1681. - PMC - PubMed
    1. Frasure-Smith N, Lesperance F. Depression and anxiety as predictors of 2-year cardiac events in patients with stable coronary artery disease. Arch Gen Psychiatry. 2008;65(1):62–71. - PubMed

Publication types