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Meta-Analysis
. 2012 Jul 1;5(4):401-5.
doi: 10.1161/CIRCHEARTFAILURE.112.967299. Epub 2012 Jun 26.

Habitual coffee consumption and risk of heart failure: a dose-response meta-analysis

Elizabeth Mostofsky  1 , Megan S Rice, Emily B Levitan, Murray A Mittleman
Affiliations
Meta-Analysis

Habitual coffee consumption and risk of heart failure: a dose-response meta-analysis

Elizabeth Mostofsky et al. Circ Heart Fail. .

Abstract

Background: There have been discrepant findings on the association between coffee consumption and risk of incident heart failure.

Methods and results: We conducted a systematic review and a dose-response meta-analysis of prospective studies that assessed the relationship between habitual coffee consumption and the risk of heart failure. We searched electronic databases (MEDLINE, Embase, and CINAHL) from January 1966 through December 2011, with the use of a standardized protocol. Eligible studies were prospective cohort studies that examined the association of coffee consumption with incident heart failure. Five independent prospective studies of coffee consumption and heart failure risk, including 6522 heart failure events and 140 220 participants, were included in the meta-analysis. We observed a statistically significant J-shaped relationship between coffee and heart failure. Compared with no consumption, the strongest inverse association was seen for 4 servings/day and a potentially higher risk at higher levels of consumption. There was no evidence that the relationship between coffee and heart failure risk varied by sex or by baseline history of myocardial infarction or diabetes.

Conclusions: Moderate coffee consumption is inversely associated with risk of heart failure, with the largest inverse association observed for consumption of 4 servings per day.

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Figures

Figure 1
Figure 1
Selection of studies published in 1996-2011 included in a meta-analysis of coffee consumption and risk of heart failure.
Figure 2
Figure 2
Relative risk (solid line) and 95% confidence interval (dashed lines) for the association between heart failure and cups of coffee per day compared to no consumption in a meta-analysis of studies published in 2001-2011. Figure 2a represents the primary analysis including all 5 studies and Figure 2b excludes the Wilhelmsen study. Coffee consumption was modeled with restricted cubic splines in a multivariable random-effects dose-response model. The dotted line indicates the value for no association.
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