Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Sep;35(9):559-64.
doi: 10.1002/clc.22022. Epub 2012 Jun 27.

Association between Tp-e/QT ratio and prognosis in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

Xiangmei Zhao  1 , Zhouliang Xie, Yingjie Chu, Lei Yang, Wenkai Xu, Xianzhi Yang, Xiaoyu Liu, Lixiao Tian
Affiliations

Association between Tp-e/QT ratio and prognosis in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

Xiangmei Zhao et al. Clin Cardiol. 2012 Sep.

Abstract

Background: Both the Tpeak-Tend interval (Tp-e) and the Tp-e/QT ratio have been linked to increased risk for arrhythmia. Patient Tp-e/QT ratios were investigated prior to primary percutaneous coronary intervention (pPCI) in patients with ST-segment elevation myocardial infarction (STEMI).

Hypothesis: Tp-e/QT ratio maybe associated with the prognosis in patients with ST-segment elevation.

Methods: A total of 338 patients (N = 338) with STEMI treated by pPCI were included. The Tp-e and Tp-e/QT ratio were determined using electrocardiograms in the subjects exhibiting ST-segment elevation.

Results: The Tp-e/QT ratio was correlated with both short- and long-term outcomes. Analysis of the receiver operating characteristic curve demonstrated that the optimal cutoff value for outcome prediction was a Tp-e/QT ratio of 0.29. Of the 388 patients enrolled, 115 (34.0%) exhibited a Tp-e/QT ratio ≥ 0.29. Patients with a Tp-e/QT ratio ≥ 0.29 showed elevated rates of both in-hospital death (21.9% vs 2.3%; P < 0.001) and main adverse cardiac events (MACE) (48.1% vs 15.3%; P < 0.005). After discharge, Tp-e/QT ratios ≥ 0.29 remained an independent predictor of all-cause death (35.5% vs 5.2%, P < 0.001) and cardiac death (32.3% vs 2.6%, P < 0.001).

Conclusions: The Tp-e/QT ratio may serve as a prognostic predictor of adverse outcomes after successful pPCI treatment in STEMI patients.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Receiver operating characteristic (ROC) curves of the Tp‐e/QT ratio for death (a) and major adverse cardiac event (MACE) (b) during hospitalization. A cutoff value of 0.29 resulted in optimal sensitivity and specificity.
Figure 2
Figure 2
Receiver operating characteristic (ROC) curves of the Tp‐e/QT ratio for death from any cause (a) and cardiac death (b) after discharge. A cutoff value of 0.29 resulted in optimal sensitivity and specificity
Figure 3
Figure 3
Kaplan‐Meier plots of the incidence of death from any cause (A) and cardiac death (B).
See this image and copyright information in PMC

References

    1. Cannon CP, Greenberg BH. Risk stratification and prognostic factors in the post‐myocardial infarction patient. Am J Cardiol. 2008;102:13G–20G. - PubMed
    1. Huikuri HV, Raatikainen MJ, Moerch‐Joergensen R, et al. Prediction of fatal or near‐fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction. Eur Heart J. 2009;30:689–698. - PMC - PubMed
    1. Kuriachan V, Exner DV. Role of risk stratification after myocardial infarction. Curr Treat Options Cardiovasc Med. 2009;11:10–21. - PubMed
    1. Dekker JM, Crow RS, Hannan PJ, et al. Heart rate‐corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle‐aged men and women: the ARIC study. J Am Coll Cardiol. 2004;43:565–571. - PubMed
    1. Goldenberg I, Mathew J, Moss AJ, et al. Corrected QT variability in serial electrocardiograms in long QT syndrome: the importance of the maximum corrected QT for risk stratification. J Am Coll Cardiol. 2006;48:1047–1052. - PubMed

Publication types