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. 2012 Jul;194(14):3756-7.
doi: 10.1128/JB.00692-12.

Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506)

Carlos Barreiro  1 , Carlos Prieto, Alberto Sola-Landa, Elena Solera, Miriam Martínez-Castro, Rosario Pérez-Redondo, Carlos García-Estrada, Jesús F Aparicio, Lorena T Fernández-Martínez, Javier Santos-Aberturas, Zahra Salehi-Najafabadi, Antonio Rodríguez-García, Andreas Tauch, Juan F Martín
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Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506)

Carlos Barreiro et al. J Bacteriol. 2012 Jul.

Abstract

The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.

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References

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