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. 2012 Feb;3(2):303-306.
doi: 10.3892/ol.2011.377. Epub 2011 Nov 24.

Serum levels of cystatin C in elderly lung cancer patients

Gen Ohara  1 , Kunihiko Miyazaki, Koichi Kurishima, Katsunori Kagohashi, Hiroichi Ishikawa, Hiroaki Satoh, Nobuyuki Hizawa
Affiliations

Serum levels of cystatin C in elderly lung cancer patients

Gen Ohara et al. Oncol Lett. 2012 Feb.

Abstract

The purpose of this study was to confirm the correlation between serum levels of cystatin C (Cys-C) and those of creatinine (Cre), the most widely used index of renal function in clinical practice, and to evaluate serum levels of Cys-C, with a particular focus on the effects of aging, body mass index (BMI), C-reactive protein (CRP) and disease extent in patients with lung cancer. Serum Cys-C levels in a total of 39 patients (median 72 years), who were diagnosed as having lung cancer were analyzed retrospectively. The serum Cys-C was determined using colloidal gold particles coated with anti-Cys C antibodies. A significant correlation coefficient was found between serum levels of Cys-C and those of Cre (P=0.001), but only moderate agreement. Serum Cys-C levels increased in an age-dependent manner with significant differences among 3 age groups: patients younger than 65 years, those aged 65 to 74 years and those aged 75 years or older (P=0.001). However, no correlation was observed between Cys-C and BMI, Cys-C and CRP, or Cys-C and disease extent of lung cancer. Estimation of renal function is important since renal insufficiency is directly correlated to increased chemotherapeutic complications in oncological practice. Thus, estimation of serum Cys-C levels may be important, but adjustment of Cys-C for age should be taken into consideration.

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Figures

Figure 1
Figure 1
Serum levels of Cys-C and age. Serum levels of Cys-C increased in an age-dependent manner with significant differences (P=0.007, Kruskal-Wallis test). Cys-C, cystatin C.
Figure 2
Figure 2
Correlation between the serum levels of Cys-C and age in 39 lung cancer patients. The correlation coefficient between them was significant (Spearman’s ρ=0.452, P=0.004). Cys-C, cystatin C.
Figure 3
Figure 3
Serum levels of Cys-C in 17 advanced lung cancer patients with carcinomatous pleuritis and/or pericarditis, and/or metastatic disease were identical to those in 22 lung cancer patients without carcinomatous pleuritis and/or pericarditis or distant metastases. Cys-C, cystatin C.
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