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. 2012 Mar;3(3):654-658.
doi: 10.3892/ol.2011.527. Epub 2011 Dec 19.

Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer

Xudong Zhao  1 , Nianfei Wang, Mingjun Zhang, Shaoli Xue, Kaihu Shi, Zhendong Chen
Affiliations

Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer

Xudong Zhao et al. Oncol Lett. 2012 Mar.

Abstract

The aim of this study was to detect methylation of the RAR-β gene in tissues from non-small cell lung cancer (NSCLC) patients. The methylation of the RAR-β gene in DNA from 80 cases with NSCLC and corresponding non-malignant tissues was tested using methylation-specific polymerase chain reaction (PCR; MSP). The results showed that the total frequency of RAR-β methylation was significantly higher in lung cancer tissues compared to the corresponding non-malignant tissues (57.5 vs. 17.5%) (P<0.01). However, no significant difference was found in various clinical stages and types of lung cancer (P>0.05). A significant difference was observed in the various pathological types (P<0.05). RAR-β gene methylation is closely correlated with the development process of NSCLC, particularly squamous cell carcinoma.

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