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. 1990 Sep;15(9):933-6.
doi: 10.1007/BF00965915.

GABA-gated chloride ion influx in brains of epileptic El mice

M Ito  1 , H Tsuda, K Oguro, K Mutoh, H Shiraishi, Y Shirasaka, H Mikawa
Affiliations

GABA-gated chloride ion influx in brains of epileptic El mice

M Ito et al. Neurochem Res. 1990 Sep.

Abstract

GABA-gated chloride ion influx was measured in brain "microsac" preparations of epileptic El mice. There was significantly greater sensitivity to GABA in stimulated El mice (which had 14-18 convulsions induced at weekly intervals) than in unstimulated El mice (which had not experienced convulsions) or ddY mice. GABA-gated chloride ion influx was significantly decreased 20 min after a single convulsion, and returned to the preconvulsion level 60 min after a convulsion. These findings suggest that the functional state of GABA-gated chloride channel in El mice is changed secondarily by single or repeated convulsions.

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