Review
doi: 10.1016/j.critrevonc.2012.05.004.
Epub 2012 Jun 27.
Hierarchical organization and regulation of the hematopoietic stem cell osteoblastic niche
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- PMID: 22743345
- DOI: 10.1016/j.critrevonc.2012.05.004
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Review
Hierarchical organization and regulation of the hematopoietic stem cell osteoblastic niche
Crit Rev Oncol Hematol.
2013 Jan.
Abstract
Hematopoietic stem cells (HSCs) are characterized with long-term self-renewal and multi-lineage differentiation. HSCs preferentially reside in osteoblastic niche that is hierarchically organized so as to exactly regulate HSCs properties and maintain organism hematopoietic homeostasis. Hematopoietic stem cell-mesenchymal stem cell pairings share stem cell niches in adult bone marrow under immune-humoral-neural regulation. Here, we review the hierarchical HSC osteoblastic niche in terms of its localization, composition, function, and multi-layer regulation systems.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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