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Comment
. 2012 Jun 29;14(7):654-5.
doi: 10.1038/ncb2530.

Get on the exosome bus with ALIX

James H Hurley  1 , Greg Odorizzi
Affiliations
Comment

Get on the exosome bus with ALIX

James H Hurley et al. Nat Cell Biol. .

Abstract

Exosomes have a growing inventory of functions, but the mechanism of protein sorting into exosomes has been unclear. Now, a signal sequence first described in viral budding provides just such a cargo sorting mechanism, revealing closer-than-expected parallelism between exosome biogenesis and the ESCRT-dependent endolysosomal pathway.

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  • Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.
    Baietti MF, Zhang Z, Mortier E, Melchior A, Degeest G, Geeraerts A, Ivarsson Y, Depoortere F, Coomans C, Vermeiren E, Zimmermann P, David G. Baietti MF, et al. Nat Cell Biol. 2012 Jun 3;14(7):677-85. doi: 10.1038/ncb2502. Nat Cell Biol. 2012. PMID: 22660413

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