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Review
. 2012 Aug 1;4(8):a011288.
doi: 10.1101/cshperspect.a011288.

The hippo pathway

Kieran F Harvey  1 , Iswar K Hariharan
Affiliations
Review

The hippo pathway

Kieran F Harvey et al. Cold Spring Harb Perspect Biol. .

Abstract

The Hippo pathway regulates tissue growth, and inactivation of any of four key components (HPO, WTS, SAV, and MATS) results in tissue overgrowth. Cell junctions may also modulate the pathway's activity.

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Figures

Figure 1.
Figure 1.
The Drosophila Hippo pathway.
Figure 2.
Figure 2.
The mammalian Hippo pathway.
See this image and copyright information in PMC

References

    1. Boggiano JC, Vanderzalm PJ, Fehon RG 2011. Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. Dev Cell 21: 888–895. - PMC - PubMed
    1. Gilbert MM, Tipping M, Veraksa A, Moberg KH 2011. A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie. Dev Cell 20: 700–712. - PMC - PubMed
    1. Grusche FA, Richardson HE, Harvey KF 2010. Upstream regulation of the hippo size control pathway. Curr Biol 20: R574–582. - PubMed
    1. Halder G, Johnson RL 2011. Hippo signaling: Growth control and beyond. Development 138: 9–22. - PMC - PubMed
    1. Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G 2006. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 8: 27–36. - PubMed

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