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. 2012 Jul;23(13):2407-11.
doi: 10.1091/mbc.E12-01-0073.

The future of ciliary and flagellar membrane research

Robert A Bloodgood  1
Affiliations

The future of ciliary and flagellar membrane research

Robert A Bloodgood. Mol Biol Cell. 2012 Jul.

Abstract

There has been a dramatic shift of attention from the ciliary axoneme to the ciliary membrane, much of this driven by the appreciation that cilia play a widespread role in sensory reception and cellular signaling. This Perspective focuses attention on some of the poorly understood aspects of ciliary membranes, including the establishment of ciliary and periciliary membrane domains, the trafficking of membrane components into and out of these membrane domains, the nonuniform distribution of ciliary membrane components, the regulation of membrane morphogenesis, functional collaboration between the axoneme and the membrane, and the evolving field of therapeutics targeted at the ciliary membrane.

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Figures

FIGURE 1:
FIGURE 1:
Pathways for delivery of components to (A) and removal from (B) the ciliary membrane.
See this image and copyright information in PMC

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