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. 2012 Jul-Aug;53(4):380-6.
doi: 10.1016/j.psym.2012.05.002.

Health-related quality of life 'well-being' in HIV distal neuropathic pain is more strongly associated with depression severity than with pain intensity

John R Keltner  1 , Florin Vaida, Ronald J Ellis, Tobias Moeller-Bertram, Chelsea Fitzsimmons, Nichole A Duarte, Jessica Robinson-Papp, Robert H Dworkin, David B Clifford, Justin C McArthur, David M Simpson, Ann C Collier, Christina M Marra, J Hampton Atkinson, Igor Grant; CHARTER Group
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Health-related quality of life 'well-being' in HIV distal neuropathic pain is more strongly associated with depression severity than with pain intensity

John R Keltner et al. Psychosomatics. 2012 Jul-Aug.

Abstract

Background: Despite modern antiretroviral treatment, HIV-associated distal neuropathic pain (DNP) remains one of the most prevalent and debilitating complications of HIV disease. Neuropathic pain is often accompanied by depressed mood, and both pain and depression have been associated with decreased health-related quality of life (HRQOL) well-being. The relative contribution of depression and pain to worse life quality has not been addressed, however, even though a better understanding might sharpen intervention strategies.

Methods: We used the Medical Outcomes Study HIV (MOS-HIV) Health Survey and the Beck depression inventory-II and linear regression models to investigate HRQOL well-being in HIV-infected patients with DNP (n = 397) participating in an observational cohort study at six U.S. sites (CNS HIV Antiretroviral Treatment Effects Research Study, CHARTER).

Results: For this sample of patients with HIV DNP, severity of depressed mood was more highly correlated with HRQOL well-being than was pain intensity.

Conclusions: These results suggest that interventions to improve HRQOL well-being in individuals with HIV-associated DNP may need to address not only pain intensity but mood state as well.

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Conflict of interest statement

DISCLOSURE SECTION:

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Comparison of Beck Depression Inventory (BDI-II) correlation coefficient R with pain intensity correlation coefficient R, where y-axis = negative correlation coefficient R and x-axis = MOS-HIV Health Survey Scales and Dimensions. The BDI-II R is statistically larger than the pain intensity R for four out of five of the Well-Being dimension MOS-HIV Health Survey scales. Asterix (*) indicates that BDI-II R and self-reported pain intensity R are statistically different with P<0.0001. For MOS-HIV Survey scales General Health, Physical Function, Role Function, and Social Function, BDI-II R and pain intensity R are not statistically different with P-values respectively (0.11,0.33,1.0, and 0.053).
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References

    1. McArthur JC, Brew BJ, Nath A. Neurological complications of HIV infection. Lancet neurology. 2005;4:543–555. - PubMed
    1. Zhou L, Kitch DW, Evans SR, et al. Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathy. Neurology. 2007;68:2113–2119. - PubMed
    1. Ellis RJ, Rosario D, Clifford DB, et al. Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER Study. Archives of neurology. 2010;67:552–558. - PMC - PubMed
    1. Simpson DM, Schifitto G, Clifford DB, et al. Pregabalin for painful HIV neuropathy: A randomized, double-blind, placebo-controlled trial. Neurology. 2010;74:413–420. - PMC - PubMed
    1. Verma S, Estanislao L, Mintz L, et al. Controlling Neuropathic Pain in HIV. Current infectious disease reports. 2004;6:237–242. - PubMed

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