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Comment
. 2012 Jun 29;36(6):897-9.
doi: 10.1016/j.immuni.2012.06.005.

No ubiquitin anchors and fully RIGged

Lynn Verstrepen  1 , Rudi Beyaert
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Free article
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No ubiquitin anchors and fully RIGged

Lynn Verstrepen et al. Immunity. .
Free article

Abstract

Unanchored chains of ubiquitin have recently been proposed to play a role in signaling. In this issue of Immunity, Jiang et al. (2012) demonstrate that binding of free polyubiquitin to the viral RNA sensors RIG-I and MDA5 leads to their oligomerization and activation.

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