SAP signaling: a dual mechanism of action
- PMID: 22749348
- DOI: 10.1016/j.immuni.2012.06.002
SAP signaling: a dual mechanism of action
Abstract
In this issue of Immunity, Kageyama et al. (2012), Zhao et al. (2012), and Dong et al. (2012) show that the adaptor protein SAP regulates both positive and negative signals through SLAM receptors to stabilize intercellular contacts.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.Immunity. 2012 Jun 29;36(6):986-1002. doi: 10.1016/j.immuni.2012.05.016. Epub 2012 Jun 7. Immunity. 2012. PMID: 22683125 Free PMC article.
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