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Review
. 2012 Aug;181(2):376-9.
doi: 10.1016/j.ajpath.2012.06.006. Epub 2012 Jun 29.

A brief history of anti-VEGF for the treatment of ocular angiogenesis

Leo A Kim  1 , Patricia A D'Amore
Affiliations
Review

A brief history of anti-VEGF for the treatment of ocular angiogenesis

Leo A Kim et al. Am J Pathol. 2012 Aug.

Abstract

In 1994, The American Journal of Pathology published a key article reporting that hypoxic retina produces vascular endothelial growth factor (VEGF), suggesting a role for VEGF in ocular neovascularization. Subsequent developments in anti-VEGF treatment for neovascular eye disease have improved visual outcomes and changed the standard of care in retinal medicine and ophthalmology.

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