Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jul 1;15(8):1111-3.
doi: 10.1038/nn.3151.

Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities

Ana M M Oliveira  1 , Thekla J Hemstedt, Hilmar Bading
Affiliations

Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities

Ana M M Oliveira et al. Nat Neurosci. .

Abstract

Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. Moreover, we found that Dnmt3a2 is an activity-regulated immediate early gene that is partly dependent on nuclear calcium signaling and that hippocampal Dnmt3a2 levels determine cognitive abilities in both young adult and aged mice.

PubMed Disclaimer

Comment in

References

    1. J Biol Chem. 2002 Oct 11;277(41):38746-54 - PubMed
    1. Gerontologia. 1973;19(3):138-52 - PubMed
    1. Trends Biochem Sci. 2006 Feb;31(2):89-97 - PubMed
    1. J Biol Chem. 1987 Jul 25;262(21):9948-51 - PubMed
    1. FEBS Lett. 2001 Jun 1;498(1):1-5 - PubMed

Publication types

MeSH terms

Substances