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. 2012 Nov-Dec;46(10):828-32.
doi: 10.1097/MCG.0b013e3182500de8.

Lymphocytic esophagitis: a diagnosis of increasing frequency

Shirley Cohen  1 , Aditi Saxena, Akbar K Waljee, Cyrus Piraka, Julianne Purdy, Henry Appelman, Barbara McKenna, B Joseph Elmunzer, Amit G Singal
Affiliations

Lymphocytic esophagitis: a diagnosis of increasing frequency

Shirley Cohen et al. J Clin Gastroenterol. 2012 Nov-Dec.

Abstract

Background: Despite being found with increasing frequency on esophageal biopsies, the clinical significance of lymphocytic esophagitis (LE) remains poorly understood.

Goals: The primary aim of our study was to characterize the clinical presentation and natural history of LE among adult patients.

Study: We retrospectively reviewed records for all 81 adult patients at the University of Michigan Medical Center who had a histopathologic diagnosis of LE between January 1998 and November 2009. Patient demographics, clinical history, laboratory data, and imaging results from the time of diagnosis were obtained through review of computerized medical records. A telephone survey was conducted to collect natural history data.

Results: The number of LE diagnoses increased over time, with 81.5% (n=66) of patients being diagnosed in the last 3 years. The most frequent symptoms at the time of presentation were dysphagia (n=54), chest/abdominal pain (n=36), and heartburn (n=38). The majority (58.6%) of patients reported improvement in their initial gastrointestinal symptoms-most commonly associated with initiation of a proton pump inhibitor. Upon follow-up, most patients reported a good quality of life and satisfaction with their current health status.

Conclusions: LE is a new clinical entity with an increasing incidence. LE seems to have a benign natural history, with most patients reporting an improvement in symptoms and satisfaction with their health-related quality of life. Prospective studies are needed to better characterize the natural history and potential treatments for this clinical entity.

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Conflict of interest statement

Conflicts of Interest: None of the authors have any financial interests or conflicts of interest with the subject matter discussed in this manuscript.

Figures

Figure 1
Figure 1
Incidence of Lymphocytic Esophagitis
See this image and copyright information in PMC

References

    1. Rubio CA, Sjodahl K, Lagergren J. Lymphocytic esophagitis: a histologic subset of chronic esophagitis. Am J Clin Pathol. 2006 Mar;125(3):432–437. - PubMed
    1. Purdy JK, Appelman HD, Golembeski CP, McKenna BJ. Lymphocytic esophagitis: a chronic or recurring pattern of esophagitis resembling allergic contact dermatitis. Am J Clin Pathol. 2008 Oct;130(4):508–513. - PubMed
    1. Ware J, Jr., Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996 Mar;34(3):220–233. - PubMed
    1. Muller S, Puhl S, Vieth M, Stolte M. Analysis of symptoms and endoscopic findings in 117 patients with histological diagnoses of eosinophilic esophagitis. Endoscopy. 2007 Apr;39(4):339–344. - PubMed
    1. Straumann A, Spichtin HP, Grize L, Bucher KA, Beglinger C, Simon HU. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology. 2003 Dec;125(6):1660–1669. - PubMed

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