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. 2012 Jul;20(7):1294-6.
doi: 10.1038/mt.2012.121.

Converting scar to muscle in the injured heart

Paul R Riley  1
Affiliations

Converting scar to muscle in the injured heart

Paul R Riley. Mol Ther. 2012 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Scar to muscle conversion after myocardial infarction in a periostin-LacZ reporter mouse. (a) Activated β-gal+ (blue) fibroblasts lay down collagen fibers and establish a scar to patch the lost muscle tissue. Retroviral infection by three cardiac-inducing factors—Gata4, Mef2c, and Tbx5 (GMT)—reprograms a proportion of the fibroblasts to form induced cardiomyocytes (iCMs), which not only replaces lost endogenous CMs but also modulates the scar region for repopulation. (b) β-gal+ iCMs are structurally and functionally similar to endogenous CMs, and their maturation is probably a product of the local environment, including signals from activated epicardial cells (EPDCs).
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