Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jul;20(7):1294-6.
doi: 10.1038/mt.2012.121.

Converting scar to muscle in the injured heart

Paul R Riley  1
Affiliations

Converting scar to muscle in the injured heart

Paul R Riley. Mol Ther. 2012 Jul.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Scar to muscle conversion after myocardial infarction in a periostin-LacZ reporter mouse. (a) Activated β-gal+ (blue) fibroblasts lay down collagen fibers and establish a scar to patch the lost muscle tissue. Retroviral infection by three cardiac-inducing factors—Gata4, Mef2c, and Tbx5 (GMT)—reprograms a proportion of the fibroblasts to form induced cardiomyocytes (iCMs), which not only replaces lost endogenous CMs but also modulates the scar region for repopulation. (b) β-gal+ iCMs are structurally and functionally similar to endogenous CMs, and their maturation is probably a product of the local environment, including signals from activated epicardial cells (EPDCs).
See this image and copyright information in PMC

References

    1. Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L.et al. (2012In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes Naturee-pub ahead of print 18 April 2012. - PMC - PubMed
    1. Takahashi K., and, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–676. - PubMed
    1. Hanna JH, Saha K., and, Jaenisch R. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell. 2010;143:508–525. - PMC - PubMed
    1. Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flugel L.et al. (2010Patient-specific induced pluripotent stem-cell models for long-QT syndrome N Engl J Med 3631397–1409. - PubMed
    1. Itzhaki I, Maizels L, Huber I, Zwi-Dantsis L, Caspi O, Winterstern A.et al. (2011Modelling the long QT syndrome with induced pluripotent stem cells Nature 471225–229. - PubMed

Publication types

MeSH terms