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. 2012 Sep;56(9):4965-8.
doi: 10.1128/AAC.00830-12. Epub 2012 Jul 2.

Serotype and clonal evolution of penicillin-nonsusceptible invasive Streptococcus pneumoniae in the 7-valent pneumococcal conjugate vaccine era in Italy

Giovanni Gherardi  1 , Fabio D'Ambrosio, Daniela Visaggio, Giordano Dicuonzo, Maria Del Grosso, Annalisa Pantosti
Affiliations

Serotype and clonal evolution of penicillin-nonsusceptible invasive Streptococcus pneumoniae in the 7-valent pneumococcal conjugate vaccine era in Italy

Giovanni Gherardi et al. Antimicrob Agents Chemother. 2012 Sep.

Erratum in

  • Antimicrob Agents Chemother. 2012 Nov;56(11):6073

Abstract

The percentage of invasive penicillin-nonsusceptible pneumococci (PNSSP) isolated in Italy in the seven-valent pneumococcal conjugate vaccine (PCV7) era moderately increased in comparison to the pre-PCV7 era. Increase of nonvaccine serotypes was observed among PNSSP. The most frequent PNSSP clones were the same as those identified in the pre-PCV7 era, although they were present in different proportions. Clonal expansion, emergence of new clones, and acquisition of penicillin resistance by established clones contributed to the maintenance of penicillin resistance.

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Figures

Fig 1
Fig 1
Bar chart showing changes in the relative frequencies of the major PNSSP clones causing IPD in Italy identified before (1999 to 2003) and after (2006 to 2010) the introduction of PCV7. The serotypes expressed by each clone are indicated.
See this image and copyright information in PMC

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