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. 2012 Sep;35(9):1925-30.
doi: 10.2337/dc11-2476. Epub 2012 Jun 29.

Glucose response curve and type 2 diabetes risk in Latino adolescents

Joon Young Kim  1 , Dawn K Coletta, Lawrence J Mandarino, Gabriel Q Shaibi
Affiliations

Glucose response curve and type 2 diabetes risk in Latino adolescents

Joon Young Kim et al. Diabetes Care. 2012 Sep.

Abstract

Objective: In adults, the shape of the glucose response during an oral glucose tolerance test (OGTT) prospectively and independently predicts type 2 diabetes. However, no reports have described the utility of this indicator in younger populations. The purpose of this study was to compare type 2 diabetes risk factors in Latino adolescents characterized by either a monophasic or biphasic glucose response during an OGTT.

Research design and methods: A total of 156 nondiabetic Latino adolescents completed a 2-h OGTT. Monophasic and biphasic groups were compared for the following type 2 diabetes risk factors: fasting and 2-h glucose, HbA(1c), glucose area under the curve (AUC), insulin sensitivity (Matsuda index), insulin secretion (insulinogenic index), and β-cell function as measured by the disposition index (insulin sensitivity × insulin secretion).

Results: Of the participants, 107 youth were categorized as monophasic and 49 were biphasic. Compared with the monophasic group, participants with a biphasic response exhibited lower HbA(1c) (5.4 ± 0.3 vs. 5.6 ± 0.3%, P < 0.01) and lower glucose AUC (14,205 ± 2,382 vs. 16,230 ± 2,537 mg ⋅ dL(-1) ⋅ h(-1), P < 0.001) with higher insulin sensitivity (5.4 ± 3.2 vs. 4.6 ± 3.4, P ≤ 0.05), higher insulin secretion (2.1 ± 1.3 vs. 1.8 ± 1.3, P = 0.05), and better β-cell function (10.3 ± 7.8 vs. 6.0 ± 3.6, P < 0.001). Differences persisted after adjusting for age, sex, and BMI.

Conclusions: These data suggest that the glycemic response to an OGTT may differentiate risk for type 2 diabetes in youth. This response may be an early marker of type 2 diabetes risk among high-risk youth.

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Figures

Figure 1
Figure 1
Glucose (A) and insulin (B) response curves during OGTT in monophasic (white circle and dashed line) and biphasic (black circle and solid line) groups. *P < 0.05, **P < 0.01, ***P < 0.001.
Figure 2
Figure 2
Hyperbolic relationship between insulin sensitivity and insulin secretion in monophasic (white circle and dashed line) and biphasic (black circle and solid line) groups.
See this image and copyright information in PMC

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