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. 2012 Aug 6;51(32):8037-40.
doi: 10.1002/anie.201202575. Epub 2012 Jun 29.

Ugi/aldol sequence: expeditious entry to several families of densely substituted nitrogen heterocycles

Zhigang Xu  1 , Fabio De Moliner, Alexandra P Cappelli, Christopher Hulme
Affiliations

Ugi/aldol sequence: expeditious entry to several families of densely substituted nitrogen heterocycles

Zhigang Xu et al. Angew Chem Int Ed Engl. .

Abstract

All it takes is the Aldol: Nitrogen containing heterocycles have been assembled by means of unprecedented domino processes, designed to take advantage of diversity assembly via strategically decorated Ugi products. The aldol reaction is the second common denominator which enables sequences of up to 5 steps in one pot producing unique molecular architecture in rapid fashion.

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Figures

Scheme 1
Scheme 1
Design of Ugi-Aldol sequence.
Scheme 2
Scheme 2
Synthetic route leading to hybrid pyridinone-3-yl-benzimidazol-2-ones 8
Scheme 3
Scheme 3
The domino process leading to compounds 12
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