A.S.P.E.N. clinical guidelines: nutrition support of neonatal patients at risk for necrotizing enterocolitis
- PMID: 22753618
- DOI: 10.1177/0148607112449651
A.S.P.E.N. clinical guidelines: nutrition support of neonatal patients at risk for necrotizing enterocolitis
Abstract
Background: Necrotizing enterocolitis (NEC) is one of the most devastating diseases in the neonatal population, with extremely low birth weight and extremely preterm infants at greatest risk.
Method: A systematic review of the best available evidence to answer a series of questions regarding nutrition support of neonates at risk of NEC was undertaken and evaluated using concepts adopted from the Grading of Recommendations, Assessment, Development and Evaluation working group. A consensus process was used to develop the clinical guideline recommendations prior to external and internal review and approval by the A.S.P.E.N. Board of Directors. RESULTS/ CONCLUSIONS: (1) When and how should feeds be started in infants at high risk for NEC? We suggest that minimal enteral nutrition be initiated within the first 2 days of life and advanced by 30 mL/kg/d in infants ≥ 1, 000 g. (Weak) (2) Does the provision of mother's milk reduce the risk of developing NEC? We suggest the exclusive use of mother's milk rather than bovine-based products or formula in infants at risk for NEC. (Weak) (3) Do probiotics reduce the risk of developing NEC? There are insufficient data to recommend the use of probiotics in infants at risk for NEC. (Further research needed.) (4) Do nutrients either prevent or predispose to the development of NEC? We do not recommend glutamine supplementation for infants at risk for NEC (Strong). There is insufficient evidence to recommend arginine and/or long chain polyunsaturated fatty acid supplementation for infants at risk for NEC. (Further research needed.) (5) When should feeds be reintroduced to infants with NEC? There are insufficient data to make a recommendation regarding time to reintroduce feedings to infants after NEC. (Further research needed.).
Comment in
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Nutrition support of neonatal patients at risk for necrotizing enterocolitis: response to Fallon et al (2012).JPEN J Parenter Enteral Nutr. 2013 Jan;37(1):11. doi: 10.1177/0148607112459358. Epub 2012 Sep 12. JPEN J Parenter Enteral Nutr. 2013. PMID: 22972878 No abstract available.
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Response to the letter to the editor regarding Nutrition support of neonatal patients at risk for necrotizing enterocolitis.JPEN J Parenter Enteral Nutr. 2013 Jan;37(1):12. doi: 10.1177/0148607112461377. Epub 2012 Sep 18. JPEN J Parenter Enteral Nutr. 2013. PMID: 22990614 No abstract available.
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Necrotizing enterocolitis in preterm infants.JPEN J Parenter Enteral Nutr. 2013 Jan;37(1):13. doi: 10.1177/0148607112463437. Epub 2012 Oct 15. JPEN J Parenter Enteral Nutr. 2013. PMID: 23070132 No abstract available.
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Response to Meyer and Gortner.JPEN J Parenter Enteral Nutr. 2013 Jan;37(1):13-4. doi: 10.1177/0148607112466109. Epub 2012 Nov 20. JPEN J Parenter Enteral Nutr. 2013. PMID: 23169900 No abstract available.
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