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Comment
. 2012 Jul 1;35(7):899-900.
doi: 10.5665/sleep.1942.

"No thanks, coffee keeps me awake": individual caffeine sensitivity depends on ADORA2A genotype

Hans-Peter Landolt  1
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Comment

"No thanks, coffee keeps me awake": individual caffeine sensitivity depends on ADORA2A genotype

Hans-Peter Landolt. Sleep. .
No abstract available

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Figures

Figure 1
Figure 1
Genetic variation of ADORA2A modulates the rebound of EEG delta oscillations (0.75-4.5 Hz) after sleep loss. Delta activity in baseline (circles) and recovery (triangles) nights across consecutive NREM sleep episodes was expressed as a percentage of the all-night value in baseline (NREM sleep stages 1-4, horizontal dashed line). Data represent means ± SEM in carriers of HT4 (black symbols, n = 14) and non-HT4 haplotype (gray symbols, n = 31) alleles of ADORA2A. Forty hours prolonged wakefulness induced a larger relative rebound in delta activity in HT4 haplotype than in non-HT4 haplotype (“haplotype” × “night” × “NREM sleep episode”: F6,125 = 68.95, P < 0.0001). *P < 0.02 (HT4 vs. non-HT4, unpaired 2-tailed t-test). Figure corresponds to supplementary Figure S3 in (re-plotted with permission).
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