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. 2012 Jan;33(1):1-6.
doi: 10.4103/0971-5851.96960.

Endometrial stromal sarcoma: A review of the literature

Geetha Puliyath  1 , M Krishnan Nair
Affiliations

Endometrial stromal sarcoma: A review of the literature

Geetha Puliyath et al. Indian J Med Paediatr Oncol. 2012 Jan.

Abstract

Endometrial stromal sarcomas are rare malignant tumors of the uterus, and most of the information available in literature is based on small series or case reports. A proper preoperative diagnosis is difficult and in most cases the diagnosis is confirmed after hysterectomy for a presumed benign disease. Endometrial sampling, ultrasound, and magnetic resonance imaging can provide diagnostic clues. Total hysterectomy with bilateral salpingo-oopherectomy is the main line of management and for early disease complete cure is a reality. Ovarian conservation may be possible in young women with early stage disease and the role of lymphadenectomy is controversial. Adjuvant hormone therapy in the form of progesterone, gonadotropin releasing hormone analogues, and aromatase inhibitors are found to be effective in preventing recurrences. Hormone therapy, radiotherapy and surgical excision of the metastasis are recommended for recurrences.

Keywords: Endometrial stromal sarcoma; malignant uterine tumor; uterine sarcoma.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Endometrial stromal sarcoma uniform oval or spindle shaped neoplastic cells invading myometrium
Figure 2
Figure 2
Adjuvant therapy
See this image and copyright information in PMC

References

    1. Tavassoli FA, Devilee P. WHO Classification of Pathology and genetics of tumours of the breast and female genital organs. In: Tavassoli FA, Devilee P, editors. Lyon, France: IARC Press; 2003. pp. 233–6.
    1. Micci F, Panagopoulos I, Bjerkehagen B, Heim S. Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma. Cancer Res. 2006;66:107–12. - PubMed
    1. Halbwed I, Ullmann R, Kremser ML, Man YG, Moud NI, Lax S, et al. Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridization. Gynecol Oncol. 2005;2:582–7. - PubMed
    1. Cohen I. Endometrial pathologies associated with postmenopausal tamoxifen treatment. Gynecol Oncol. 2004;2:256–66. - PubMed
    1. Nicolas ML, Cathro HP, Kerr SE, Stelow EB. Cytomorphologicfeatures of low-grade endometrial stromal sarcoma. AJR Am J ClinPathol. 2007;128:265–71. - PubMed