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Case Reports
. 2012 Apr;4(2):128-31.
doi: 10.4103/0974-777X.96779.

Multisystem Sarcoidosis in a Patient on Interferon-α Therapy for Chronic Hepatitis C

Bouchra Oudghiri  1 , Mohammed Benzagmout, Saïd Boujraf, Fawzi Belahcen, Adil Ibrahimi
Affiliations
Case Reports

Multisystem Sarcoidosis in a Patient on Interferon-α Therapy for Chronic Hepatitis C

Bouchra Oudghiri et al. J Glob Infect Dis. 2012 Apr.

Abstract

Sarcoidosis is a chronic multisystemic granulomatous disease that is triggered by an autoimmune process. Nowadays, this pathology represents a well-recognized but uncommon complication for antiviral treatment in hepatitis C virus (HCV) infection. Herein, we report a remarkable case of 47-year-old woman treated for chronic HCV infection; the patient has developed interferon alfa-induced sarcoidosis involving the central nervous system. The evolution was fatal despite disrupting the antiviral therapy and initiating a high-dose corticotherapy. This complication of interferon alfa treatment was reported in the literature in only one case. Through this case and a review of the literature, we aim to underline the importance of screening for sarcoidosis before and during the follow-up of HCV patients undergoing antiviral therapy.

Keywords: Chronic hepatitis C; Complication; Interferon alfa; Neurosarcoidosis; Treatment.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
No caseating epithelioid granuloma formation composed of macrophages, lymphocytes, and fibroblasts
Figure 2
Figure 2
Cerebral MRI in postgadolinium axial T1-weighted image (a) and FLAIR image (b), showing a gyriform and nodular left frontal and parietal subcortical enhancement associated with an important perilesional edema
See this image and copyright information in PMC

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