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. 2012;13(5):6440-6451.
doi: 10.3390/ijms13056440. Epub 2012 May 24.

Phytochemical and biological studies of Agave attenuata

Komal Rizwan  1 , Muhammad Zubair  1 , Nasir Rasool  1 , Muhammad Riaz  1 , Muhammad Zia-Ul-Haq  2 , Vincenzo De Feo  3
Affiliations

Phytochemical and biological studies of Agave attenuata

Komal Rizwan et al. Int J Mol Sci. 2012.

Abstract

The present study was conducted to examine various biological activities of a methanol extract of Agave attenuata leaves. GC-MS analysis of the n-hexane fraction from the extract revealed the presence of 31 compounds, with mono-2-ethylhexyl phthalate (11.37%), 1,2-benzenedicarboxylic acid (6.33%), n-docosane (6.30%) and eicosane (6.02%) as the major components. The leaves contained appreciable levels of total phenolic contents (10.541-39.35 GAE, mg/100 g) and total flavonoid contents (43.35-304.8 CE, mg/100 g). The extract and some of its fractions showed moderate antimicrobial effects. Leaves extract and fractions also exhibited a good antioxidant potential when measured by DPPH radical scavenging activity and inhibition of lipid peroxidation assays. The hemolytic effect of the plant was found to be in a range of 1.01%-2.64%. From the present study it is concluded that this plant could be used as a source of natural antioxidants and functional food nutraceutical applications.

Keywords: Agave attenuata; GC-MS; flavonoids; peroxidation; phenolics; volatile fraction.

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