Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 May;6(2):314-8.
doi: 10.1159/000338837. Epub 2012 May 23.

Gastric metastasis from a primary renal leiomyosarcoma

Satoshi Yodonawa  1 , Isao Ogawa, Susumu Yoshida, Hiromichi Ito, Akinori Kato, Ryoko Kubokawa, Emika Tokoshima, Hiroaki Shimoyamada
Affiliations
Case Reports

Gastric metastasis from a primary renal leiomyosarcoma

Satoshi Yodonawa et al. Case Rep Gastroenterol. 2012 May.

Abstract

Primary leiomyosarcoma of the kidney is rare. Here we report a case of metastasis of this tumor to the stomach. A 73-year-old man visited our hospital suffering from general weakness and intermittent tarry stools. He had undergone right nephrectomy for renal leiomyosarcoma 2 years previously. There had been no local recurrence or distant metastasis in the 2-year follow-up period. Endoscopy revealed two submucosal tumors in the stomach. These tumors were diagnosed histologically as leiomyosarcoma and distal gastrectomy was performed. Subsequent histochemical staining confirmed the diagnosis of gastric metastasis from renal leiomyosarcoma. The patient died due to metastases to the liver and bone 9 months after the operation. To the best of our knowledge, this is the first report of gastric metastasis from primary renal leiomyosarcoma.

Keywords: Gastrectomy; Gastric metastasis; Nephrectomy; Renal leiomyosarcoma.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
a Macroscopic findings for the resected specimen. The tumor formed a circumscribed, solid, white mass at the lower pole of the right kidney. b Histopathologically, the tumor was composed of spindle cells arranged in interlacing fascicles, with elongated, hyperchromatic nuclei and eosinophilic cytoplasm. Two mitotic figures per 10 high-power fields were noted (hematoxylin-eosin staining, ×200).
Fig. 2
Fig. 2
Upper gastrointestinal endoscopy revealed two submucosal tumors: a polypoid tumor located at the anterior wall of the middle body (a) and an ulcerated tumor located at the posterior wall of the middle body (b).
Fig. 3
Fig. 3
Histopathological examination of the gastric tumor showed spindle cells with marked pleomorphism by hematoxylin-eosin staining (×200). The number of mitotic figures was 40–50 per 10 high-power fields (a). Histochemical staining of the gastric tumor was positive for SMA (b), negative for CD34 (c) and negative for c-kit (d) by immunohistological staining (×200).
See this image and copyright information in PMC

References

    1. Menuck LS, Amberg JR. Metastatic disease involving the stomach. Am J Dig Dis. 1975;20:903–913. - PubMed
    1. Riviello C, Tanini I, Cipriani G, Pantaleo P, Nozzoli C, Poma A, Riccardo P, Valeri A. Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: a case report and a review of literature. World J Gastroenterol. 2006;32:5234–5236. - PMC - PubMed
    1. Venkatesh K, Lamba Saini M, Niveditha SR, Krishnagiri C, Babu S. Primary leiomyosarcoma of the kidney. Patholog Res Int. 2010;2010:652398. - PMC - PubMed
    1. Buchman AL, Truong LD. Colonic metastasis from a primary renal leiomyosarcoma: an unusual cause of gastrointestinal hemorrhage. South Med J. 1997;90:1238–1240. - PubMed
    1. Oda I, Kondo H, Yamao T, Ono H, Gotoda T, Yamaguchi H, Yoshida S, Shimoda T. Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases. Endoscopy. 2001;33:507–510. - PubMed

Publication types