Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jul;63(3):260-3.
doi: 10.1007/s12070-011-0165-2. Epub 2011 Apr 13.

Myeloperoxydase expression in the pathogenesis of nasal polyps

Burcin A Sarisoy, Mehmet Eken, Alev Z Oktay, Mustafa Paksoy, Arif Sanli

Myeloperoxydase expression in the pathogenesis of nasal polyps

Burcin A Sarisoy et al. Indian J Otolaryngol Head Neck Surg. 2011 Jul.

Abstract

Nasal polyps are benign mucosal protrusions that expand into the nasal cavity. There are no any etiological factors that may explain the pathogenesis of nasal polyps but currently inflammation continues to be the major factor. As a result of inflammation, neutrophils become activated and migrate to the inflammatory area and form their bactericidal effects by producing free oxygen radicals. The objective of our study is to investigate the expression of myeloperoxydase enzyme, which is usually an indicator of leukocyte infiltration and is responsible in the formation of free oxygen radicals in polyp tissues and to determine its role in the pathogenesis of nasal polyps.

Keywords: Free oxygen radicals; Inflammation; Myeloperoxidase; Nasal polyps.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Distribution of epithelial cell stained with MPO in all tissues
Fig. 2
Fig. 2
Distrubution of inflammatory cells stained with MPO in all tissues
Fig. 3
Fig. 3
Distribution of epithelial cells stained with MPO between groups
Fig 4
Fig 4
Distrubution of inflammatory cells stained with MPO between groups
See this image and copyright information in PMC

References

    1. Bachert C, Gevaert P, Holtappels G, Cuvelier C, Cauwenberge P. Nasal polyposis: from cytokines to growth. Am J Rhinol. 2000;14:279–290. doi: 10.2500/105065800781329573. - DOI - PubMed
    1. Ozcan C, Polat A, Otag F, Gorur K. Does Helicobacter pylori play a role in etiology of nasal polyposis? Auris Nasus Larynx. 2009;14:427–430. doi: 10.1016/j.anl.2008.09.007. - DOI - PubMed
    1. Pawankar R. Nasal polyposis: an update: editorial review. Curr Opin Allergy Clin Immunol. 2003;3:1–6. doi: 10.1097/00130832-200302000-00001. - DOI - PubMed
    1. Kennedy DW, Bolger WE, Zinreich SJ (2001) Nasal polyposis In: Diseases of the sinuses, therapy and management. B.C.Decker, Philedelphia, pp 69–75
    1. Drake-Lee A (1997) The pathogenesis of nasal polyps. In: Nasal polyps: epidemiology, pathogenesis and treatment. OceanSide Publications Inc., Rhode Islands, pp 57–64

LinkOut - more resources