Alzheimer’s disease: the new promise
- PMID: 22754953
- PMCID: PMC3314477
- DOI: 10.1172/jci62745
Alzheimer’s disease: the new promise
Abstract
Clinical vignette: A 59-year-old aeronautical engineer is referred to you for evaluation because of increasing difficulty with job performance over the last several years. Difficulty managing home finances, getting lost driving, and forgetting appointments have become common. Previously outgoing, he is now depressed and irritable. After appropriate neurologic assessment, including brain imaging and metabolic studies, you make the diagnosis of Alzheimer’s dementia and are asked by the patient’s family what treatment is available.
Comment on
-
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.J Clin Invest. 2012 Apr;122(4):1339-53. doi: 10.1172/JCI57256. J Clin Invest. 2012. PMID: 22476196 Free PMC article.
-
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.J Clin Invest. 2012 Apr;122(4):1316-38. doi: 10.1172/JCI59903. J Clin Invest. 2012. PMID: 22476197 Free PMC article.
