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. 2012 Jul 3:6:182.
doi: 10.1186/1752-1947-6-182.

Minor salivary gland mucoepidermoid carcinoma in children and adolescents: a case series and review of the literature

Priyanshi Ritwik  1 , Kitrina G Cordell, Robert B Brannon
Affiliations

Minor salivary gland mucoepidermoid carcinoma in children and adolescents: a case series and review of the literature

Priyanshi Ritwik et al. J Med Case Rep. .

Abstract

Introduction: Because well-documented cases of mucoepidermoid carcinomas that are of minor salivary gland origin and occur in children and adolescents have rarely been reported, little information regarding their clinical features and biologic behavior is available. This case report represents a retrospective clinical analysis of five minor salivary gland mucoepidermoid carcinomas accessioned from a 35-year period at the Louisiana State University School of Dentistry and combines the data with 15 well-documented cases from the English language literature.

Case presentation: The five mucoepidermoid carcinomas in patients from birth to 19 years of age accounted for 1.3% of the accessioned minor salivary gland neoplasms. There were an additional 15 well-documented cases in the literature. Combining the data for the 20 mucoepidermoid carcinomas resulted in a mean age of 13.5 years and a 2.3:1 female-to-male ratio. Collectively, the hard palate, soft palate, and hard palate/soft palate junction accounted for 85% of the cases. Thirty-five percent of the cases presented as a fluctuant submucosal swelling with surface color alterations. The average duration was five months, and bone involvement occurred in seven cases. A histologic grade of low to intermediate predominated (95%). Surgical removal was the treatment in all cases. Thirteen cases had adequate follow-up of three years or more, and recurrence was documented in only one case. There were no cases of death or metastasis in this series.

Conclusions: In children and adolescents, mucoepidermoid carcinomas have a female predilection and occur most commonly on the hard or soft palate or both. A fluctuant submucosal lump with a bluish color is a helpful diagnostic clue. The histologic grades of most mucoepidermoid carcinomas in the first and second decades of life are low and, to a lesser degree, intermediate. Complete surgical excision is the treatment of choice and results in a recurrence rate of less than 10%.

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Figures

Figure 1
Figure 1
Age distribution of patients with mucoepidermoid carcinoma.
Figure 2
Figure 2
Site distribution of mucoepidermoid carcinoma in children and adolescents.
Figure 3
Figure 3
Photomicrograph of hematoxylin-and-eosin-stained section of mucoepidermoid carcinoma.
Figure 4
Figure 4
Photomicrograph of hematoxylin-and-eosin-stained section of mucoepidermoid carcinoma.
Figure 5
Figure 5
Photomicrograph of hematoxylin-and-eosin-stained section of mucoepidermoid carcinoma.
Figure 6
Figure 6
Photomicrograph of hematoxylin-and-eosin-stained section of mucoepidermoid carcinoma.
See this image and copyright information in PMC

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