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. 2012 Sep;21(9):1542-6.
doi: 10.1158/1055-9965.EPI-12-0483. Epub 2012 Jul 3.

Seroprevalence of human papillomavirus (HPV) type 6 and 16 vary by anatomic site of HPV infection in men

Beibei Lu  1 , Raphael P Viscidi, Yougui Wu, Alan G Nyitray, Luisa L Villa, Eduardo Lazcano-Ponce, Roberto J Carvalho da Silva, Maria Luiza Baggio, Manuel Quiterio, Jorge Salmerón, Danelle C Smith, Martha Abrahamsen, Mary Papenfuss, Anna R Giuliano
Affiliations

Seroprevalence of human papillomavirus (HPV) type 6 and 16 vary by anatomic site of HPV infection in men

Beibei Lu et al. Cancer Epidemiol Biomarkers Prev. 2012 Sep.

Abstract

Background: It is largely unknown if antihuman papillomavirus (HPV) serum antibody responses vary by anatomic site of infection in men.

Methods: This study assessed type-specific anti-HPV serum antibody prevalence associated with corresponding HPV DNA detection in the external genitalia and the anal canal of 1,587 heterosexual men and 199 men who have sex with men (MSM).

Results: We observed that HPV 6 and 16 seroprevalence was higher in the presence of same HPV-type infection in the anal canal compared with same HPV-type infection in the external genitalia only, and among MSM compared with the heterosexual men. Seropositivity to HPV 6 was strongly associated with HPV 6 DNA detection in the anal canal but not in the external genitalia alone among both heterosexual men [adjusted prevalence ratio (APR), anal+/genital+ vs. anal-/genital-: 4.2, 95% confidence interval (CI), 11.7-10.5; anal+/genital- vs. anal-/genital-: 7.9 (95% CI, 3.7-17.0)] and MSM [APR, anal+/genital+ vs. anal-/genital-: 5.6 (95% CI, 2.7-11.9); anal+/genital- vs. anal-/genital-: 3.2 (95% CI, 2.1-4.9)]. Similar associations between seropositivity to HPV 16 and anal HPV 16 DNA detection were only observed in MSM [anal+/genital+ vs. anal-/genital-: 3.1 (95% CI, 2.0-5.0); anal+/genital- vs. anal-/genital-: 2.2 (95% CI, 1.3-3.5)].

Conclusion: Our data showed that seroprevalence varied by anatomic site of HPV infection, suggesting differences in epithelium type present at these anatomic sites may be relevant.

Impact: Our finding is instrumental in advancing our understanding of immune mechanism involved in anatomic site-specific antibody response.

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Figures

Figure 1
Figure 1
Serum antibody levels (Median, inter-quartile range, minimum and maximum) corresponding to anogenital site-specific HPV detection among HPV positive men.
See this image and copyright information in PMC

References

    1. IARC . Human papillomaviruses/IARC working group on the evaluation of carcinogenic risks to humans. International Agency for Research on Cancer; Lyon, France: 2007.
    1. Hernandez BY, McDuffie K, Zhu X, Wilkens LR, Killeen J, Kessel B, et al. Anal human papillomavirus infection in women and its relationship with cervical infection. Cancer Epidemiol Biomarkers Prev. 2005;14:2550–6. - PMC - PubMed
    1. Vardas E, Giuliano AR, Goldstone S, Palefsky JM, Moreira ED, Jr., Penny ME, et al. External genital human papillomavirus prevalence and associated factors among heterosexual men on 5 continents. J Infect Dis. 2011;203:58–65. - PMC - PubMed
    1. Tiggelaar SM, Lin MJ, Viscidi RP, Ji J, Smith JS. Age-specific human papillomavirus antibody and deoxyribonucleic acid prevalence: a global review. J Adolesc Health. 2012;50:110–31. - PMC - PubMed
    1. Lu B, Viscidi RP, Lee JH, Wu Y, Villa LL, Lazcano-Ponce E, et al. Human Papillomavirus (HPV) 6, 11, 16, and 18 Seroprevalence Is Associated with Sexual Practice and Age: Results from the Multinational HPV Infection in Men Study (HIM Study). Cancer Epidemiol Biomarkers Prev. 2011;20:990–1002. - PMC - PubMed

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