Review
doi: 10.1136/archdischild-2012-301633.
Epub 2012 Jul 3.
How to use... alkaline phosphatase in neonatology
Affiliations
- PMID: 22761487
- DOI: 10.1136/archdischild-2012-301633
Item in Clipboard
Review
How to use... alkaline phosphatase in neonatology
Arch Dis Child Educ Pract Ed.
2012 Aug.
Abstract
Alkaline phosphatase (ALP) is regularly measured in clinical practice. Changes in serum levels are observed in a number of clinical conditions. In neonatology, it has been proposed as a useful marker for both a diagnosis and an indication of the severity of metabolic bone disease (MBD) in infants born preterm. Nutritional practices, aimed at reducing the occurrence or severity of MBD, have led to ALP being proposed as a stand-alone means of monitoring treatment. The current evidence does not support this use: ALP only achieves usefulness in a diagnostic and monitoring capacity when combined with other serum and imaging techniques.
Similar articles
-
[Osteopenia of prematurity--prophylaxis, diagnostics and treatment].Akush Ginekol (Sofiia). 2012;51(7):24-30. Akush Ginekol (Sofiia). 2012. PMID: 23610914 Bulgarian.
-
Bone Mineral Density According to Dual Energy X-ray Absorptiometry is Associated with Serial Serum Alkaline Phosphatase Level in Extremely Low Birth Weight Infants at Discharge.Pediatr Neonatol. 2017 Jun;58(3):251-257. doi: 10.1016/j.pedneo.2016.05.005. Epub 2016 Sep 30. Pediatr Neonatol. 2017. PMID: 27780689 Clinical Trial.
-
Metabolic bone disease and bone mineral density in very preterm infants.J Pediatr. 2014 Mar;164(3):499-504. doi: 10.1016/j.jpeds.2013.10.089. Epub 2013 Dec 10. J Pediatr. 2014. PMID: 24331689
-
Prematurity and bone health.World Rev Nutr Diet. 2013;106:181-8. doi: 10.1159/000342680. Epub 2013 Feb 11. World Rev Nutr Diet. 2013. PMID: 23428699 Review.
-
[Prevention of osteopenia in premature infants].Med Wieku Rozwoj. 2008 Oct-Dec;12(4 Pt 1):924-32. Med Wieku Rozwoj. 2008. PMID: 19471068 Review. Polish.
Cited by
-
Diagnostics of Metabolic Bone Disease in Extremely Preterm Infants-Clinical Applicability of Bone Turnover Biochemical Markers and Quantitative Ultrasound.Children (Basel). 2024 Jun 27;11(7):784. doi: 10.3390/children11070784. Children (Basel). 2024. PMID: 39062233 Free PMC article.
-
Higher bone mineral density at six years of age in very preterm-born infants fed human milk compared to formula feeding. A secondary analysis of an RCT.Eur J Pediatr. 2025 Jan 30;184(2):160. doi: 10.1007/s00431-024-05935-3. Eur J Pediatr. 2025. PMID: 39883214 Free PMC article. Clinical Trial.
-
"Calcium-Phosphorus-Magnesium Axis" and the Metabolic Issue of Newborns Undergoing Parenteral Nutrition: Is It Time to Change Our Perspectives?Nutrients. 2025 Feb 23;17(5):775. doi: 10.3390/nu17050775. Nutrients. 2025. PMID: 40077645 Free PMC article.
-
Bone status in preterm infant: influences of different nutritional regimens and possible markers of bone disease.J Perinatol. 2016 May;36(5):394-400. doi: 10.1038/jp.2015.212. Epub 2016 Jan 14. J Perinatol. 2016. PMID: 26765552
-
[Expert consensus on the follow-up management of bronchopulmonary dysplasia in preterm infants after discharge].Zhongguo Dang Dai Er Ke Za Zhi. 2022 May 15;24(5):455-465. doi: 10.7499/j.issn.1008-8830.2201078. Zhongguo Dang Dai Er Ke Za Zhi. 2022. PMID: 35644184 Free PMC article. Chinese.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
