Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012;8(6):e1002741.
doi: 10.1371/journal.ppat.1002741. Epub 2012 Jun 28.

How do viruses interact with stress-associated RNA granules?

Richard E Lloyd  1
Affiliations
Review

How do viruses interact with stress-associated RNA granules?

Richard E Lloyd. PLoS Pathog. 2012.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author has declared that no competing interests exist.

Figures

Figure 1
Figure 1. Stress granule and P-body assembly and interference by viruses.
Virus infection causes stress at multiple levels that reduces host translation through activation of eIF2 kinases or other means and converts active polysome mRNPs into stalled translation initiation complex mRNPs. A complex series of events involving nucleation of several stress granule marker proteins such as G3BP, Tia-1/TIAR, and HDAC6 plus transport on microtubules (MT) leads to aggregates of translation initiation complex mRNPs in stress granules. Alternatively, mRNPs can be stripped of initiation factors and ribosome subunits, associate with GW182, undergo Pan2/3-mediated deadenylation, MT transport, and association of other RNA decay factors (e.g., Xrn1, Dcp1a, DDX6, GW182 and Lsm components of the exosome), and become concentrated in P-bodies. Decapping and decay occur outside P-bodies and also within them. Specific points/proteins where viruses interact with and inhibit RNA granule assembly pathways are shown.
See this image and copyright information in PMC

References

    1. Anderson P, Kedersha N. RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol. 2009;10:430–436. - PubMed
    1. Wek RC, Jiang HY, Anthony TG. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans. 2006;34:7–11. - PubMed
    1. Arimoto K, Fukuda H, Imajoh-Ohmi S, Saito H, Takekawa M. Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways. Nat Cell Biol. 2008;10:1324–1332. - PubMed
    1. White JP, Lloyd RE. Regulation of stress granules in virus systems. Trends Microbiol. 2012;20:175–183. - PMC - PubMed
    1. Qin Q, Hastings C, Miller CL. Mammalian orthoreovirus particles induce and are recruited into stress granules at early times postinfection. J Virol. 2009;83:11090–11101. - PMC - PubMed

Publication types