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. 2012:2012:568564.
doi: 10.1155/2012/568564. Epub 2012 Jun 19.

Systemic-lupus-erythematosus-related acute pancreatitis: a cohort from South China

Yanlong Yang  1 , Yujin Ye, Liuqin Liang, Tianfu Wu, Zhongping Zhan, Xiuyan Yang, Hanshi Xu
Affiliations

Systemic-lupus-erythematosus-related acute pancreatitis: a cohort from South China

Yanlong Yang et al. Clin Dev Immunol. 2012.

Abstract

Acute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for the mortality of patients with SLE-related AP in a cohort of South China.

Methods: Inpatient medical records of SLE-related AP were retrospectively reviewed.

Results: 27 out of 4053 SLE patients were diagnosed as SLE-related AP, with an overall prevalence of 0.67%, annual incidence of 0.56‰ and mortality of 37.04%. SLE patients with AP presented with higher SLEDAI score (21.70 ± 10.32 versus 16.17 ± 7.51, P = 0.03), more organ systems involvement (5.70 ± 1.56 versus 3.96 ± 1.15, P = 0.001), and higher mortality (37.04% versus 0, P = 0.001), compared to patients without AP. Severe AP (SAP) patients had a significant higher mortality rate compared to mild AP (MAP) (75% versus 21.05%, P = 0.014). 16 SLE-related AP patients received intensive GC treatment, 75% of them exhibited favorable prognosis.

Conclusion: SLE-related AP is rare but concomitant with high mortality in South Chinese people, especially in those SAP patients. Activity of SLE, multiple-organ systems involvement may attribute to the severity and mortality of AP. Appropriate glucocorticosteroid (GC) treatment leads to better prognosis in majority of SLE patients with AP.

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Figures

Figure 1
Figure 1
Kaplan-Meier survival curves for the time (days) from onset of SLE-related acute pancreatitis to death.
Figure 2
Figure 2
Treatment regimen and outcome of the SLE-related AP.
See this image and copyright information in PMC

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