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Comparative Study
. 2012;7(6):e36691.
doi: 10.1371/journal.pone.0036691. Epub 2012 Jun 25.

Multiple Loci are associated with dilated cardiomyopathy in Irish wolfhounds

Ute Philipp  1 , Andrea Vollmar, Jens Häggström, Anne Thomas, Ottmar Distl
Affiliations
Comparative Study

Multiple Loci are associated with dilated cardiomyopathy in Irish wolfhounds

Ute Philipp et al. PLoS One. 2012.

Abstract

Dilated cardiomyopathy (DCM) is a highly prevalent and often lethal disease in Irish wolfhounds. Complex segregation analysis indicated different loci involved in pathogenesis. Linear fixed and mixed models were used for the genome-wide association study. Using 106 DCM cases and 84 controls we identified one SNP significantly associated with DCM on CFA37 and five SNPs suggestively associated with DCM on CFA1, 10, 15, 21 and 17. On CFA37 MOGAT1 and ACSL3 two enzymes of the lipid metabolism were located near the identified SNP.

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Conflict of interest statement

Competing Interests: AT is the Head of Research and Development at Antagene. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Figures

Figure 1
Figure 1. Manhattan plot of the genome-wide association study for dilated cardiomyopathy in Irish wolfhounds from Europe using a general linear model analysis.
The genome-wide p-values (–log10 p-values) for the SNP effect are plotted against marker position on each chromosome. X-axis indicates marker number. Chromosomes are differentiated by colours. Colours are given below the plot. Red line indicates threshold value of probability for significant association with DCM. Blue line indicates threshold value of probability for suggestive association with DCM.
See this image and copyright information in PMC

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