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. 2012;5(2):208-11.
doi: 10.3980/j.issn.2222-3959.2012.02.18. Epub 2012 Apr 18.

Space-occupying lesions of the lacrimal gland at one tertiary eye center in China: a retrospective clinical study of 95 patients

Xiang-Ning Wang  1 , Jiang Qian, Yi-Fei Yuan, Rui Zhang, Yan-Qing Zhang
Affiliations

Space-occupying lesions of the lacrimal gland at one tertiary eye center in China: a retrospective clinical study of 95 patients

Xiang-Ning Wang et al. Int J Ophthalmol. 2012.

Abstract

Aim: To investigate the treatment status and prognosis of space-occupying lacrimal gland lesions at one tertiary eye center in China.

Methods: A retrospective clinical study was performed on 95 patients with space-occupying lesions of the lacrimal gland surgically treated at the Eye & ENT Hospital of Fudan University from 2003 to 2007. The reviewed clinical data included age, gender, side of the lesion, duration of signs and symptoms, histopathological diagnosis, treatment modality, recurrence (local, regional, and distant metastasis) and survival.

Results: Of the 95 cases (99 eyes), pleomorphic adenomas were the most common lesions (43 cases), followed by lymphoid disorders (14), inflammatory pseudotumors (11), carcinoma ex-pleomorphic adenomas (11), and adenoid cystic carcinomas (ACC, 6). There were 8 patients with relapsed pleomorphic adenomas. Five of these 8 cases had malignant pathological changes. All patients with ACC had metastasis and three of them died during their follow-up.

Conclusion: Our study indicated that the most common lacrimal gland lesions were pleomorphic adenomas. Multiple recurrence and surgical procedures may increase the risk of tumor progression. ACC had a high incidence of tumor metastasis and a poor prognosis.

Keywords: China; adenoid cystic carcinoma; lacrimal gland lesions; pleomorphic adenomas.

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References

    1. Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology. 2004;111(5):997–1008. - PubMed
    1. Shields CL, Shields JA, Eagle RC, Rathmell JP. Clinicopathologic review of 142 cases of lacrimal gland lesions. Ophthalmology. 1989;96(4):431–435. - PubMed
    1. Shields JA, Shields CL, Epstein JA, Scartozzi R, Eagle RC., Jr Review: primary epithelial malignancies of the lacrimal gland: the 2003 Ramon L. Font lecture. Ophthal Plast Reconstr Surg. 2004;20(1):10–21. - PubMed
    1. Edge SB, Byrd DR, Compton CC, Fritz AG, Green FL, Trotti A. 7th ed. New York, NY: Springer; 2010. AJCC cancer staging manual; pp. 569–575.
    1. An epidemiological survey of lacrimal fossa lesions in Japan: number of patients and their sex ratio by pathological diagnosis. Jpn J Ophthalmol. 2005;49(5):343–348. - PubMed

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