Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Aug;14(8):548-53.
doi: 10.1111/j.1477-2574.2012.00498.x. Epub 2012 Jun 8.

Relevance of residual disease after liver resection for incidental gallbladder cancer

Javier C Lendoire  1 , Luis Gil, Fernando Duek, Carlos Quarin, Verónica Garay, Gabriel Raffin, Marcelo Rivaldi, Oks Alejandra, Oscar Imventarza
Affiliations

Relevance of residual disease after liver resection for incidental gallbladder cancer

Javier C Lendoire et al. HPB (Oxford). 2012 Aug.

Abstract

Objectives: In patients diagnosed with incidental gallbladder cancer (GC), the benefit and optimal extent of further surgery remain unclear. The aims of this study were to analyse outcomes in patients who underwent liver resection following a diagnosis of incidental GC and to determine factors associated with longterm survival.

Methods: A retrospective analysis of patients diagnosed with incidental GC between June 1999 and June 2010 was performed. Data covering demographics, clinical and surgical characteristics and local pathological stage were analysed.

Results: A total of 24 patients were identified. All patients underwent a resection of segments IVb and V and lymphadenectomy. Histological examination revealed residual disease in 10 patients, all of whom presented with recurrent disease at 3-12 months. Overall 5-year survival was 53%. Increasing T-stage (P < 0.001), tumour-node-metastasis (TNM) stage (P= 0.003), and the presence of residual tumour in the resected liver (P < 0.001) were all associated with worse survival.

Conclusions: Aggressive re-resection of incidental GC offers the only chance for cure, but its efficacy depends on the extent of disease found at the time of repeat surgery. The presence of residual disease correlated strongly with T-stage and was the most relevant prognostic factor for survival in patients treated with curative resection.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Five-year overall survival in 24 patients who underwent resection for incidental gallbladder cancer
Figure 2
Figure 2
Five-year overall survival in patients with tumour–node–metastasis stage II and III disease
See this image and copyright information in PMC

References

    1. Hariharan D, Saied A, Kocher HM. Analysis of mortality rates for gallbladder cancer across the world. HPB. 2008;10:327–331. - PMC - PubMed
    1. Arroyo GF. Cáncer de vesícula biliar. Oncol Clin. 2002;8:831–836.
    1. Jensen EH, Abraham A, Habermann EB, Al-Refaie WB, Vickers SM, Virnig BA, et al. A critical analysis of the surgical management of early-stage gallbladder cancer in the United States. J Gastrointest Surg. 2009;13:722–727. - PubMed
    1. Dong XD, DeMatos P, Prieto VG, Seigler HF. Melanoma of the gallbladder: a review of cases seen at Duke University Medical Center. Cancer. 1999;85:32–39. - PubMed
    1. Batra Y, Pal S, Dutta U, Gark PK, Makharia G. Gallbladder cancer in India: a dismal picture. J Gastrointest Hepatol. 2005;20:309–314. - PubMed

MeSH terms