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. 2012 Aug;78(12):1357-62.
doi: 10.1055/s-0032-1315001. Epub 2012 Jul 4.

Isoflavonoids from Ficus benjamina and their inhibitory activity on BACE1

Jingqiu Dai  1 , Dai Shen, Wesley Y Yoshida, Stephen M Parrish, Philip G Williams
Affiliations

Isoflavonoids from Ficus benjamina and their inhibitory activity on BACE1

Jingqiu Dai et al. Planta Med. 2012 Aug.

Abstract

Examination of an active extract of the fruit of Ficus benjamina var. nuda (Miq.) Barrett has led to the isolation of six new isoflavones and two coumarano-chroman-4-ones, along with fifteen known compounds. The structures of the eight new compounds were elucidated on the basis of extensive NMR experiments and mass spectrometric measurements. The inhibitory activity of the compounds on the proteolytic cleavage of amyloid precursor protein by the aspartic protease BACE1 was evaluated. Both coumarano-chroma-4-ones and some isoflavones showed moderate activity in this assay.

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Figures

Fig. 1
Fig. 1
Chemical structures of compounds 1-8.
Fig. 2
Fig. 2
Selected HMBC (H → C) correlations of 1.
Fig. 3
Fig. 3
Selected HMBC (H → C) and ROESY (↔) correlations of 3.
See this image and copyright information in PMC

References

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    1. The plant is known locally as Ficus benjamina var comosa.
    1. Anonymous. [October 17, 2011];Flora of North America. Available at: http://www.fna.org.

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