Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Sep;27(9):1174-8.
doi: 10.1177/0883073812449382. Epub 2012 Jul 4.

Cardiac involvement in hereditary ataxias

Sean Moore  1 , Subha V Raman
Affiliations
Review

Cardiac involvement in hereditary ataxias

Sean Moore et al. J Child Neurol. 2012 Sep.

Abstract

Although much attention has been focused on the neurological sequelae of the hereditary ataxias, patients with these conditions also may develop cardiac complications that represent a significant cause of disability and even death. In this article, the authors describe the hereditary ataxias with known cardiac involvement, discuss underlying causes, and review guidelines for screening and treatment. Continued progress will require coordinated clinical trial networks, interdisciplinary care teams, and team science.

PubMed Disclaimer

References

    1. Klockgether T, Paulson H. Milestones in ataxia. Mov Disord. 2011 May;26(6):1134–1141. - PMC - PubMed
    1. Schols L, Amoiridis G, Przuntek H, Frank G, Epplen JT, Epplen C. Friedreich's ataxia. Revision of the phenotype according to molecular genetics. Brain. 1997 Dec;120(Pt 12):2131–2140. - PubMed
    1. Tsou AY, Paulsen EK, Lagedrost SJ, et al. Mortality in Friedreich ataxia. J Neurol Sci. 2011 Aug 15;307(1–2):46–49. - PubMed
    1. Harding AE, Hewer RL. The heart disease of Friedreich's ataxia: a clinical and electrocardiographic study of 115 patients, with an analysis of serial electrocardiographic changes in 30 cases. Q J Med. 1983 Autumn;52(208):489–502. - PubMed
    1. Artham SM, Lavie CJ, Milani RV, Patel DA, Verma A, Ventura HO. Clinical impact of left ventricular hypertrophy and implications for regression. Prog Cardiovasc Dis. 2009 Sep-Oct;52(2):153–167. - PubMed

Publication types

MeSH terms