doi: 10.1016/j.bmcl.2012.06.028.
Epub 2012 Jun 16.
Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity
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- PMID: 22765903
- DOI: 10.1016/j.bmcl.2012.06.028
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Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity
Bioorg Med Chem Lett.
.
Abstract
The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited good in vitro antiplasmodial activity (IC(50): 0.18 μM, K1, cholorquine resistant strain).
Copyright © 2012 Elsevier Ltd. All rights reserved.
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